Join Facebook to connect with Wade M Haak Howard and others you may know. Thus, targeting the MRTF/SRF gene transcription pathway could provide an efficacious new approach to therapy for SSc and other fibrotic disorders. View the profiles of people named Wade M Haak Howard. In vivo treatment with CCG-203971 also prevented bleomycin-induced skin thickening and collagen deposition. A novel small-molecule inhibitor of MRTF/SRF-regulated transcription (CCG-203971) inhibits expression of connective tissue growth factor (CTGF), α-smooth muscle actin ( α-SMA), and collagen 1 (COL1A2) in both SSc fibroblasts and in lysophosphatidic acid (LPA)–and transforming growth factor β (TGF β)–stimulated fibroblasts. TROY DENNIS, JESSE & SANDRA EIDEM, MARIE & CRAIG FODNESS, DARWIN & SHEREE FLANDERS, JULIE HOWARD, TRUMAN URBAN-GERLAD GROVE, MARGARET & STEVEN HAMMERS. Children Exposed to Marital Conflict Exhibit More Disordered Eating Behaviors: Child Emotional. MRTF/SRF-regulated genes show spontaneously increased expression in primary dermal fibroblasts from patients with diffuse cutaneous SSc. Hwley James T 37 126-04a Haak Eva F 47 091-20a Haak Jesse C 16 091-20a. In light of evidence that a myocardin-related transcription factor (MRTF)–and serum response factor (SRF)–regulated gene transcriptional program induced by Rho GTPases is essential for myofibroblast activation, we explored the hypothesis that inhibitors of this pathway may represent novel antifibrotics. Current trials focus on anti-inflammatory drugs or targeted approaches aimed at one of the many receptor mechanisms initiating fibrosis. Teresa White's birthday is and is 59 years old.Before moving to Teresa's current city of Howard, SD, Teresa lived in Terril IA and Quitman AR.Other names that Teresa uses includes Tersea D Whilte, Teresa D Ireland and Teresa D White. Systemic sclerosis (SSc), or scleroderma, similar to many fibrotic disorders, lacks effective therapies.
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